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KMID : 0365819640040010077
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Journal of Pusan Medical College
1964 Volume.4 No. 1 p.77 ~ p.82
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Changes In Fibrinolytic Parameters During The Course of Normal Pregnancy of Koreans
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Abstract
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Alterations in various factors affecting the coagulation of blood during the course of pregnancy have been studied by several investigators. During the past two decades an intense had developed in fibrinolysis, the process by which fibrin, the matrix of blood clot, is hydrolyzed. Although various fibrinolytic mechanisms have been studied in various obstetric cases and daring normal course of the pregnancy, there have been no studies of such changes during the course of normal pregnancy in Korea.
So I hoped to determine the normal physiologic modifications of fibrinolysis occurring during the course of gestation and the possible relationships between the fibrinolytic changes occurring in association with the hemorrhagic complications and or the thrombotic manifestations of pregnancy.
seventy eight patients from the obstetric of the Pusan National University Hospital had blood samples collected in oxalate tubes during the first, second, third trimesters of pregnancy, postpartum, and nonpregnant women.
The parameters studied were the fibrinolytic activities on the standard bovine fibrinogen plate and, on the heated bovine fibrinogen plate, with or without addition of streptokinase to the plasma samples.
Plasma fibrinogen concentration which was determined by the dry weighing method, rose significantly during pregnancy and reached maximum levels(530mg/100ml.) in the third trimester and returned to normal levels (230mg/ 100L ) in the post partu m period.
Free fibrinolytic activities of the plasma of the pregnant and nonpregnant were not demonstrated on the standard and heated bovine fibrine plate. without addition of streptokinase. whole plasma activities which were determined by addition of streptokinase to the plasma of the pregnant and the nonpregnant, on the standard and heated bovine plate, rose significantly during the pregnancy, reached maximum levels in the third and full term and returned to nolmal levels in the post partum period.
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